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  Premarin
Drug uses
Estrogen is a sex hormone produced in the body of a woman in ovaries. Premarin contains a mixture of estrogens isolated from mare’s urine and used to treat menopause symptoms (itching and soreness of the vulva, warmth in the chest, painful and frequent urination, neck and face, vaginal dryness, irritation, burning).Woman’s ovaries produce less estrogen as they get older. The decreasing level of estragon in a woman’s body may lead to serious consequences including bone fragility.
It may also be used for other medical conditions such as osteoporosis, shortage of natural estrogen connected with ovarian failure, cancer both in men and women.
How taken
Premarin comes as a cream and as tablets. Premarin is taken with a glass of water, with/without food at approximately the same time daily (usually in the evening).For some conditions the course of treatment lasts for about 3 weeks with a week’s break after.
The average dose is 0.3-2.5 mg a day depending on the conditions treated and on the state of the patient.
If you are using a cream, open the tube and squeeze some cream out using the applicator and paying attention to its stopping points. Lie down on your back with the knees drawn up. Insert the applicator into the vagina and press the plunger down. Then remove it from the barrel and wash with soap in warm water.
Precautions
1 Visit your doctor regularly.
2 Inform the doctor if you have any allergies.
3 The doctor should know about any medications you are taking at the moment including vitamins and supplements. Be sure you’ve mentioned:
Antidepressants
Blood thinners
Barbiturates
Calcium supplements
Insulin or other medications for diabetes taken orally
Tranquilizers
Grapefruit juice
Steroid/thyroid medications
Medicines for convulsions
Rifampin
Itraconazole or Ketoconazole
4 Long-term Premarin increases the risk of a heart attack, dementia and breast cancer.
5 Premarin is not recommended if you have any of the following medical conditions:
Breast/uterine cancer
Heart/blood/liver/kidney problems
Unusual vaginal bleeding
6 The doctor should know if you smoke or you are overweight.
7 Make sure the doctor knows if you are pregnant.
Premarin may cause inborn defects. Breastfeeding is not recommended during the treatment.
8 You should closely examine your breasts regularly during the treatment.
9 The doctor should know if you have any specific medical conditions such as:
Diabetes
Endometriosis
Porphyria
Hysterectomy
Breast cancer
Circulation problems
Epilepsy
Gall stones
Gallbladder disease
Asthma
Too much or too little calcium in the blood
Migraines
Obesity
Fibroids of the uterus
Convulsions
Benign breast lumps
High blood pressure
10 Premarin increases the risk of endometrial hyperplasia. To reduce the risk the doctor may prescribe you progestin to be taken together with Premarin.
11 Before having any kind of surgery, tell the doctor in advance about the medicine you are taking. Perhaps you will need to discontinue using the medicine for some time before the surgery.
12 Premarin causes giddiness, that’s why you shouldn’t do anything life-threatening until you find out how your body reacts to the medicine.
13 Avoid taking alcohol drinks while using the medicine.
14 Do not use latex condoms, cervical caps or diaphragms within 72 hrs after you used the cream.
Side effects
Allergy is one of the least dangerous side effects when using Premarin. Allergic reaction is characterized by troubled breathing, swollen face, throat, lips, tongue. Darkening of the skin on your face, vaginal itching, headache, giddiness, fatigue may also occur while taking Premarin. More serious side effects demand prompt medical help: migraine, breast lump, vaginal bleeding, vision problems, sweating, problems with speech or balance, pain in the chest or stomach, vomiting, swollen limbs. Premarin may also cause fluid retention and changes in thyroid function.
Missed dose
If you missed a dose, take it as soon as possible, but if it’s nearly time to take the next dose, skip the missed one and go back to your everyday schedule. Never double doses to catch up with the missed one.
Overdose
Call the emergency if there’s a suspicion that you’ve got an overdose. The signs of overdose are vaginal bleeding, sickness, vomiting.
Storage
  • Keep away from children
  • Store at room temperature
  • Keep away from heat, cold, direct light and damp places
  • Dispose of an outdated medicine